Tetrabutylammonium Fluoride → HCID 10836187, compound

Participants

Reaction Steps

To a solution of the crude ether from Step 5 in THF (10 mL) at 0° C. was added HOAC (4 drops) followed by n-Bu4NF (1M, THF, 1.4 mL). The reaction mixture was stirred 2 hr. at 0° C. then quenched with a saturated solution of NH4Cl and diluted with Et2O. The organic phase was washed with H2O, brine, dried over MgSO4, and the solvent evaporated. The residue was purified by chromatography on silica gel using hexane/EtOAc, 7:3, to give the title product.

Provenance & Evidence