反应详情

7.04 g of 10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizine-1-carboxylic acid are suspended in 100 ml of ethyl acetate under argon and treated with 2.1 ml of oxalyl chloride. Subsequently, 0.2 ml of N,N-dimethylformamide is added, whereby an evolution of gas is observed. The mixture is left to stir at room temperature for 30 minutes, a further 0.2 ml of oxalyl chloride and thereupon 0.1 ml of N,N-dimethylformamide are added thereto and the mixture is left to stir at room temperature for a further 30 minutes. The reaction mixture is cooled to 0°-5° C. in an ice bath, whereby crystals separate. 13.3 ml of triethylamine are added and a solution of 2.53 g of (S)-3-ethoxypyrrolidine in 25 ml of ethyl acetate is subsequently added dropwise. The mixture is subsequently stirred at about 0° C. for 30 minutes, washed twice with 50 ml of water each time and the combined aqueous phases are extracted once with 20 ml of ethyl acetate. The combined organic phases are dried over sodium sulphate, filtered and evaporated, whereby 9.0 g of crude product are obtained. The crude product is dissolved in 50 ml of methylene chloride and filtered through 45 g of silica gel (methylene chloride/acetone 9:1), whereby 8.6 g of yellow crystals are obtained. These are taken up in 100 ml of tert.-butyl methyl ether and heated to reflux for 1 hour. The mixture is left to cool to room temperature and the crystals (6.95 g) are filtered off under suction. 5.5 g the thus-obtained crude product are recrystallized from 55 ml of ethyl acetate, whereby, for crystallization, the mixture is cooled in an ice bath. After drying at 80° C./0.05 mm (18 hrs.) there are obtained 4.2 g of (S)-1-[(10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quinolizin-1-yl)carbonyl]-3-ethoxypyrrolidine of m.p. 134°-136° C.

1. waitThe mixture is left
2. waitthe mixture is left
3. stirringto stir at room temperature for a further 30 minutes
4. temperatureThe reaction mixture is cooled to 0°-5° C. in an ice bath
5. customwhereby crystals separate
6. addition13.3 ml of triethylamine are added
7. additiona solution of 2.53 g of (S)-3-ethoxypyrrolidine in 25 ml of ethyl acetate is subsequently added dropwise
8. stirringThe mixture is subsequently stirred at about 0° C. for 30 minutes
9. washwashed twice with 50 ml of water each time
10. extractionthe combined aqueous phases are extracted once with 20 ml of ethyl acetate
11. dry with materialThe combined organic phases are dried over sodium sulphate
12. filtrationfiltered
13. customevaporated
14. customwhereby 9.0 g of crude product are obtained
15. filtrationfiltered through 45 g of silica gel (methylene chloride/acetone 9:1), whereby 8.6 g of yellow crystals
16. customare obtained
17. temperatureheated
18. temperatureto reflux for 1 hour
19. waitThe mixture is left
20. temperatureto cool to room temperature
21. filtrationthe crystals (6.95 g) are filtered off under suction
22. custom5.5 g the thus-obtained crude product
23. customare recrystallized from 55 ml of ethyl acetate, whereby, for crystallization
24. temperaturethe mixture is cooled in an ice bath
25. customAfter drying at 80° C./0.05 mm (18 hrs.) there