Bromotrimethylsilane → HCID 23190956, compound

HRID 1198773Notes

Reaction equation

HRID 1198773 reaction equation
C([O:3][P:4]([CH:9]([NH:18][CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[P:10]([O:15]CC)(=[O:14])[O:11]CC)(=[O:8])[O:5]CC)C.C[Si](C)(C)Br>ClCCl>[O:22]([CH2:21][CH2:20][CH2:19][NH:18][CH:9]([P:10]([OH:15])(=[O:11])[OH:14])[P:4]([OH:5])(=[O:3])[OH:8])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 76113BromotrimethylsilaneHCID 53686113HCID 53686113, compound

Product 1

HCID 23190956HCID 23190956, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.0 g (0.0068 mol) of N-(3-phenoxypropyl)aminomethanediphosphonic acid tetraethyl ester are dissolved in 20 ml of dichloromethane, and 4.4 ml (0.0343 mol) of trimethylbromosilane are added. After 72 hours at room temperature, the solvent is removed under reduced pressure. The remaining oil is dissolved in warm 95% aqueous methanol. On cooling, N-(3-phenoxypropyl)aminomethanediphosphonic acid of m.p. 226°-228° (decomp.) is obtained.

Workup

  1. customthe solvent is removed under reduced pressure
  2. dissolutionThe remaining oil is dissolved in warm 95% aqueous methanol
  3. temperatureOn cooling

Sources & evidence

ORD record
ord-fe6cc976f9974989979b81988246c979
Source dataset
uspto-grants-1994_01
Patent number
US05281748

Reaction notes

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