Ammonia → HCID 23374766, compound

Participants

Reaction Steps

73.4 g (0.264 mol) of ethyl P-(4-cyanobut-3-yl)-P-(diethoxymethyl)-phosphinate in 770 ml of dry ethanol are treated with 126 g of an 8% solution of ammonia in ethanol. Subsequently, 15 g of Raney-nickel and the resulting mixture is hydrogenated at 45° under atmospheric pressure. The catalyst is then filtered of and the filtrate is concentrated under reduced pressure. The crude product is distilled in vacuo to yield the ethyl P-(5-aminopent-3-yl)-P-(diethoxymethyl)-phosphinate (b.p.: 100°/0.01 Torr).

Provenance & Evidence