Hydrochloric Acid → HCID 178491465, compound

Participants

Reaction Steps

A solution of 16.3 g of p-[trans-4-(p-anisyloxymethyl)-cyclohexyl]benzoyl chloride in 50 ml of dichloroethane is cooled to 7° C. and treated portionwise under nitrogen within 5 minutes with 6.4 g of powdered aluminium chloride. A weak stream of acetylene gas is then conducted through the reaction mixture at 45° C. for 17 hours. The reaction mixture is subsequently poured into 100 ml of ice-water, treated with 50 ml of 3N hydrochloric acid and stirred for 10 minutes. The mixture is extracted with diethyl ether. The organic phase is washed in succession with water, with 5 percent potassium hydroxide solution and several times with water, then dried over magnesium sulphate and evaporated. The trans-4-(p-anisyloxymethyl)-1-[p-(3-chloroacryloyl)phenyl]cyclohexane obtained is purified by chromatography on silica gel.

Provenance & Evidence