HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrofluoric Acid → HCID 15611582, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrofluoric Acid | HCID 14917 | — |
| Reactant | HCID 15611580 | HCID 15611580 | — |
| Product | HCID 15611582 | HCID 15611582 | — |
Reaction Steps
The epoxide ring of the 9β,11β-epoxy-6α-fluoro-17α-hydroxy-16α-methyl-4-pregnene-3,20-dione is opened by means of hydrogen fluoride, and 6α,9α-difluoro-11β,17 -dihydroxy-16α-methyl-4-pregnene-3,20-dione is obtained. The conditions under which this reaction step is performed are also conventional (J. Fried et al. Organic Reactions in Steroid Chemistry, van Nostrand Reinhold Co., New York et al., Vol. 1, 1972, 425 ff).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898693 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-66fd9441030b409397e1be50dc4d6a74 |
| Source note | uspto-grants-1990_02 |