4-Chlorobenzylamine → HCID 10471279, compound

Participants

Reaction Steps

A 1 g quantity of ethyl 2-ethoxycarbonylamino-4,5-dimethyl-3-thiophenecarboxylate and 1 g of 4-chlorobenzylamine were dissolved in a mixture of 3 ml of ethanol and 1 ml of N,N-dimethylformamide and the mixture was allowed to react in a sealed tube at 230° C. for 7 hours. The reaction mixture was concentrated and the residue was recrystallized from an acetone-ethanol-dimethylformamide mixture, giving 0.8 g of 3-(4-chlorobenzyl)-5,6-dimethylthieno[2,3-d]pyrimidin-2,4(1H,3H)-dione having a melting point of 291° to 292° C. in a yield of 68%.

Provenance & Evidence