Ethyl bromoacetate → HCID 15085549, compound

Participants

Reaction Steps

A 1.2 g quantity of 3-hexyl-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-2,4(1H,3H)-dione (Compound III-9), 0.14 g of 50% sodium hydride and 1.0 g of ethyl bromoacetate were allowed to react with each other in the same manner as in Reference Example 5. The residue obtained by concentration was subjected to silica gel column chromatography using chloroform as an eluent. Then 1.2 g of 1-ethoxycarbonylmethyl-3-hexyl-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-2,4(1H,3H)-dione was obtained in a yield of 77%.

Provenance & Evidence