Bis-(1H-imidazol-2-YL)-methanone → HCID 19867717, compound

Participants

Reaction Steps

A solution of carbonyl diimidazole (0.33 g) in tetrahydrofuran (THF) (2 cm3) was added dropwise to a stirred solution of 3,4-dihydro-4,8-dimethyl-6-[(N-2-aminophenyl)amino]-2-(1H)-quinolone (0.24 g) in THF (2 cm3) at room temperature (20°). After 2 hours the solvent was evaporated in vacuo and the residue chromatographed on silica (Merck "MK 60.9385" [Trade Mark]) eluting with ethyl acetate. Collection and evaporation of appropriate fractions afforded a solid which was recrystallised from ethyl acetate to give the title compound, m.p. 250°-254° (0.13 g).

Provenance & Evidence