Sodium Hydroxide → HCID 19867702, compound

Participants

Reaction Steps

Stannous chloride dihydrate (45.9 g) was added portionwise to a stirred solution of 1-(3-methyl-4-nitrophenyl)-2-methylbenzimidazole (9.2 g) in absolute ethanol (200 cm3) under nitrogen. After heating under reflux for 1 hour, the cooled mixture was basified to pH 9 with aqueous 2.5M sodium hydroxide and extracted with chloroform (3×200 cm3). The combined and dried (MgSO4) organic extracts were evaporated in vacuo to give the title compound (8.9 g) which was characterised spectroscopically then used directly in Preparation 12 without further purification.

Provenance & Evidence