Bis-(1H-imidazol-2-YL)-methanone → 2-Methoxy-6-(2-oxobenzimidazol-1-yl)-8-methylquinoline

HRID 1198938Notes

Reaction equation

HRID 1198938 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([CH3:21])[CH:7]=[C:8]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[NH2:20])[CH:9]=2)[N:4]=1.[C:22](C1NC=CN=1)(C1NC=CN=1)=[O:23]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[C:6]([CH3:21])[CH:7]=[C:8]([N:13]3[C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=4[NH:20][C:22]3=[O:23])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 5250894Bis-(1H-imidazol-2-YL)-methanoneHCID 544931382-methoxy-6-[(N-2-aminophenyl)-amino]-8-methylquinoline

Product 1

HCID 198677092-Methoxy-6-(2-oxobenzimidazol-1-yl)-8-methylquinoline

Procedure

This compound, m.p. 280°, was prepared similarly to Example 16 using 2-methoxy-6-[(N-2-aminophenyl)-amino]-8-methylquinoline, and carbonyl diimidazole as starting materials. The product was characterised spectroscopically and used directly in Example 3 without further purification.

Workup

  1. customused directly in Example 3 without further purification

Sources & evidence

ORD record
ord-5654695eac4d4b82bad9c9c78b6eb364
Source dataset
uspto-grants-1990_02
Patent number
US04898872

Reaction notes

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