Methane → HCID 19867724, compound

Participants

Reaction Steps

A suspension of 4-methyl-6-amino-8-methyl-2-(1H)-quinolone (0.38 g) in absolute ethanol (50 cm3) was hydrogenated at 100° and 2000 p.s.i. (13.7×106Pa) pressure over 10% palladised charcoal (0.05 g) for 72 hours. The cooled solution was then filtered through "Solkafloc" (Trade mark for a cellulose-base filtering aid) and evaporated in vacuo to give a solid which was chromtographed on silica (Merck "MK 60.9385" [Trade Mark]) eluting with methanol:chloroform, 1:50 by volume. Combination and evaporation of appropriate fractions gave a residue which on trituration with ethyl acetate afforded the title compound, m.p. 207°-10°, (0.22 g).

Provenance & Evidence