HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Toluidine → 3-Methyl-N-(2-methylphenyl)but-2-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Toluidine | HCID 7242 | — |
| Reactant | 3-Methyl-2-butenoyl chloride | HCID 102394 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-Methyl-N-(2-methylphenyl)but-2-enamide | HCID 19177433 | — |
Reaction Steps
3-Methylbut-2-en-oylchloride (24.2 g) was added dropwise to a stirred solution of 2-methylaniline (20 g) in anhydrous pyridine (200 cm3) cooled to 0°. After 1 hour solvent was evaporated in vacuo to yield a solid which was recrystallised from ether/petroleum ether (boiling range 40-60) to afford the title compound, m.p. 105 (29.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898872 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-75b2d942296f4a8e86311197647a3f77 |
| Source note | uspto-grants-1990_02 |