N-bromobutanimide → HCID 15634755, compound

Participants

Reaction Steps

A solution of 23.5 g (0.112 mole) of 7-methyl-3-phenyl-2,1-benzisoxazole in 400 ml of carbon tetrachloride was treated with 20.0 g (0.112 mole) of N-bromosuccinimide and the mixture was heated at reflux with a white light lamp until all solid floated in the solvent. The mixture was filtered and the filtrate deposited a 15 g crop of reasonably pure product. This 15 g of material was dissolved in methylene chloride and washed with diluted sodium hydroxide to remove succinimide. The organic solution was concentrated and the residue was crystallized from isopropanol to give 25.2 g (77%) of yellow needles, m.p. 125.0°-125.5° C.

Provenance & Evidence