Water → HCID 15634757, compound

Participants

Reaction Steps

A mixture of 17.3 g (0.06 mole) of 7-bromomethyl-3-phenyl-2,1-benzisoxazole, 17 g of potassium cyanide, 80 ml of water and 120 ml of dioxane was heated at reflux under a nitrogen atmosphere for 2 hr. The mixture was then cooled and diluted with 300 ml of methylene chloride. The organic layer was separated, washed with water and dried over magnesium sulfate. The solvents were removed under vacuum and the residue was crystallized twice from absolute ethanol to give 10.3 g (74%) of yellow crystals, m.p. 125°-138° C.

Provenance & Evidence