N-bromobutanimide → HCID 14835362, compound

Participants

Reaction Steps

A mixture of 9.7 g (0.0427 mole) of 3-(4-fluorophenyl)-7-methyl-2,1-benzisoxazole, 7.7 g (0.0431 mole) of N-bromosuccinimide and 0.2 g of dibenzoyl peroxide in 300 ml of carbon tetrachloride was heated at reflux under floodlight illumination and under an argon atmosphere for 3.5 hr. The cooled reaction mixture was filtered and the filtrate was concentrated under reduced pressure to give 10.4 g of solid. The solid was recrystallized twice from 2-propanol to give 9.0 g (69%) of light-yellow, fluffy needles, m.p. 145°-148° C.

Provenance & Evidence