反应详情

A mixture of 15.7 g (0.065 mole) of 3-(4-chlorophenyl)-7-methyl-2,1-benzisoxazole, 11.6 g (0.065 mole) of N-bromosuccinimide, 0.5 g of dibenzoylperoxide and 400 ml of carbon tetrachloride was heated at reflux while being illuminated by a flood lamp for 3 hr. The mixture was filtered and the filtrate was concentrated to give a solid as residue. The solid was recrystallized three times from acetonitrile to yield 12.0 g (58%) of crystals, m.p. 153°-155° C.

1. temperaturewas heated
2. temperatureat reflux
3. customwhile being illuminated by a flood lamp for 3 hr
4. filtrationThe mixture was filtered
5. concentrationthe filtrate was concentrated
6. customto give a solid as residue
7. customThe solid was recrystallized three times from acetonitrile