Acetic Acid → HCID 14835373, compound

Participants

Reaction Steps

A solution of 175 ml of 30% hydrogen peroxide and 600 ml of glacial acetic acid was heated on a steam bath for 1 hr and cooled. The solution was treated with 36.8 g (0.15 mole) of (2-amino-5-chloro-3-methylphenyl)phenylmethanone and the mixture was heated at 55°-70° C. for 7 hr and let stand overnight at ambient temperature. The mixture was diluted with 2 liters of water and the solid was collected by filtration, washed with water and dried. The solid was recrystallized from 2-propanol to yield 18.2 g (50%) of pale-yellow needles, m.p. 108°-109° C.

Provenance & Evidence