Benzoyl Peroxide → HCID 14835374, compound

Participants

Reaction Steps

A mixture of 16.2 g (0.067 mole) of 5-chloro-7-methyl-3-phenyl-2,1-benzisoxazole, 11.9 g (0.067 mole) of N-bromosuccinimide, 275 ml of carbon tetrachloride and 0.1 g of dibenzoylperoxide was heated at reflux under illumination of a flood lamp for 2 hr. The mixture was filtered and the filtrate was washed once with a saturated sodium bicarbonate solution, dried over sodium sulfate and concentrated to give a yellow solid as residue. An NMR analysis of the residue showed it was a mixture containing 8% of starting methyl compound, 83% of monobromo compound and 9% of dibromo compound. An analytical sample, m.p. 142°-144° C., was obtained by recrystallizing twice from ethyl acetate.

Provenance & Evidence