Acetic Acid → HCID 14835377, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 300 ml of glacial acetic acid and 150 ml of 30% hydrogen peroxide was heated on a steam bath for 1 hr, cooled, and treated with 28.0 g (0.1 mole) of (2-amino-5-chloro-3-methylphenyl)(4-chlorophenyl)methanone. The mixture was heated to 95° C. and 450 ml of acetic acid was added to dissolve all solids. The stirred mixture was heated at 60°-70° C. for 5 hr, poured into 2.5 liters of water and let stand at ambient temperature overnight. The solid was collected by filtration, washed with water and recrystallized from 2-propanol to yield 12.3 g (44%) of fluffy, off-white solid, m.p. 151°-152° C.

Provenance & Evidence