Hydrogen Peroxide → HCID 14835381, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 130 ml of 30% hydrogen peroxide in 350 ml of glacial acetic acid was heated on a steam bath for 1 hr and then cooled. To the cooled solution was added 31.0 g (0.0955 mole) of (2-amino-5-chloro-3-methylphenyl)(4-bromophenyl)methanone followed by 450 ml of glacial acetic acid. The reaction mixture was heated to 95° C. to dissolve all solids, heated at 65°-70° C. for 8 hr and then cooled. The reaction mixture was poured into 2.5 liters of ice water and let stand at ambient temperature for 3 hr and filtered. The filter cake was washed with 500 ml of 10% sodium bicarbonate solution and 500 ml of water and dried to give 22.5 g of solid. The solid was recrystallized from 2-propanol to give 20.5 g (67%) of fluffy yellow needles, m.p. 163°-165° C.

Provenance & Evidence