Water → HCID 14835400, compound

Participants

Reaction Steps

A slurry of 4.0 g (0.017 mole) of 3-phenyl-2,1-benzisoxazol-7-acetonitrile in 175 ml of t-butanol was heated to reflux and treated with 5 g (0.09 mole) of powdered potassium hydroxide. The deep blue colored reaction mixture was heated at reflux for 0.5 hr, cooled and poured into 800 ml of water. The mixture was extracted with three 100 ml portions of methylene chloride. The combined extracts were washed with water, dried over sodium sulfate, and concentrated to give a brown solid as residue. The solid was recrystallized from 2-propanol (charcoal) and then subjected to vacuum sublimation at 160°-170° C. to yield 0.5 g (12%) of an off-white powder, m.p. 191°-192° C. after recrystallization from absolute ethyl alcohol.

Provenance & Evidence