HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 14209206, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Piperidinol, 1-methyl- | HCID 66048 | — |
| Reactant | 3-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone | HCID 14182404 | — |
| Product | HCID 14209206 | HCID 14209206 | 19.7% |
Reaction Steps
Working in a manner similar to that described in Example 6, but starting with 1-methyl-4-piperidinol (4.3 g), sodium hydride (0.9 g) and 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (12.4 g), and heating the reaction mixture for 90 minutes under reflux, 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1-methyl-4-piperidyloxy)-1-isoindolinone (3 g), m.p. 204° C., is obtained after recrystallization in ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898871 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-975fb1d1273545a2b206107efca965d2 |
| Source note | uspto-grants-1990_02 |