HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 19867693, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone | HCID 14182404 | — |
| Reactant | 38052-77-6 | HCID 15881135 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19867693 | HCID 19867693 | 32.1% |
Reaction Steps
The procedure is as in Example 22, but starting with N-isopropylglycolamide (5.3 g) in tetrahydrofuran (250 cc), an oily suspension (50% by weight; 2.2 g) of sodium hydride and 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (10 g). After purification by recrystallization in acetonitrile, [2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyloxy]-N-isopropylacetamide (4 g), m.p. 188° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898871 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-920b64c0dd9548d8819b45e2c43bcac9 |
| Source note | uspto-grants-1990_02 |