HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 19867660, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 3-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone | HCID 14182404 | — |
| Reactant | N-(2-methylpropyl)glycolamide | HCID 19867653 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19867660 | HCID 19867660 | 52.3% |
Reaction Steps
The procedure is as in Example 22, but starting with N-(2-methylpropyl)glycolamide (8.9 g) in tetrahydrofuran (357 cc), an oily suspension (50% by weight; 3.3 g) of sodium hydride and 3-chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (15 g). After recrystallization in ethanol, [2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1isoindolinyloxy]-N-(2-methylpropyl)acetamide (10.1 g), m.p. 146° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898871 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-dea3083db9d342138e16e3a8da3814a8 |
| Source note | uspto-grants-1990_02 |