HCID 19867644, compound → HCID 19867665, compound

Participants

Reaction Steps

[2-(7-Methoxy-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyloxy]acetic acid may be prepared in the following manner: a solution of tert-butyl [2-(7-methoxy-1,8-naphthyridin-2-yl)-1-isoindolinyloxy]acetate (29.4 g) in trifluoroacetic acid is stirred for 2 hours at a temperature in the region of 25° C. The reaction mixture is then concentrated to dryness and the residue obtained is stirred in isopropyl ether (200 cc). The crystallized solid obtained is separated by filtration and then taken up with water (400 cc). The mixture is brought to pH 10 with 4N aqueous sodium hydroxide solution. An insoluble product is separated by filtration; the filtrate is washed with ethyl acetate (3×200 cc) and then acidified to pH 2 with 4N aqueous hydrochloric acid solution. The precipitate obtained is separated by filtration, washed with water and dried in the air. [2-(7-Methoxy-1,8-naph-thyridin-2-yl)-1-isoindolinyloxy]acetic acid (14.6 g), m.p. 190° C., is thereby obtained.

Provenance & Evidence