1,4-Dioxa-8-azaspiro(4.5)decane → HCID 70374363, compound

Participants

Reaction Steps

The procedure is as in Example 44, but starting with [2-(7-methoxy-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyloxy]acetic acid (3 g) in anhydrous dimethylformamide (65 cc), N,N'-carbonyldiimidazole (1.35 g) and 1,4-dioxa-8-azaspiro[4.5]decane (1 g). After two successive recrystallizations in carbon tetrachloride and isopropyl ether, 2-(7-methoxy-1,8-naphthyridin-2-yl)-3-[2-(4-ethylenedioxypiperidino)-2-oxoethoxy]-1-isoindolinone (2.8 g), m.p. 137° C., is obtained.

Provenance & Evidence