HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 19867680, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | — |
| Reactant | 3-Chloro-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone | HCID 14182404 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19867680 | HCID 19867680 | 30.5% |
Reaction Steps
The procedure is as in Example 22, but starting with 1-(2-hydroxyethyl)-4-acetylpiperazine (7.75 g) in anhydrous tetrahydrofuran (250 cc), an oily suspension (50% by weight; 2.3 g) of sodium hydride and 3-chloro-2(-7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (10 g). After crystallization successively in 2-propanol and then in ethanol, 3-[2-(4-acetyl-1-piperazinyl)ethoxy]-2-(7-chloro-1,8-naphthyridin-2-yl)-1-isoindolinone (4.3 g), m.p. 172° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898871 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-5190eb5d0891479fa83706965863be3e |
| Source note | uspto-grants-1990_02 |