Piperidin-4-ol → HCID 19867675, compound

Participants

Reaction Steps

The procedure is as in Example 44, but starting with [2-(7-methoxy-1,8-napthyridin-2-yl)-3-oxo-1-isoindolinyloxy] acetic acid (3.5 g) in anhydrous dimethylformamide (70 cc), N,'-carbonyldiimidazole (1.6 g) and 4-hydroxypiperidine (0.82 g). After recrystallization in ethanol, 3-[2-(4-hydroxy-1-piperidyl)-2-oxoethoxy]-2-(7-methoxy-1,8-naphthyridin-2-yl)-1-isoindolinone (3.7 g), m.p. 167° C., is obtained.

Provenance & Evidence