HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (3-Methoxyphenyl)acetic acid | HCID 15719 | — |
| Reactant | Iodine chloride | HCID 24640 | — |
| Catalyst | Iodine | HCID 807 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(2-Iodo-5-methoxyphenyl)acetic acid | HCID 820071 | 65% |
Reaction Steps
A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898889 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-577c39de1e3b494d871a067200fb5e1c |
| Source note | uspto-grants-1990_02 |