Formic Acid → HCID 14879076, compound

Participants

Reaction Steps

A solution of 35.4 g (0.126 mole) of α,β-diethyl-3,4,5-trimethoxy-N-methylbenzeneethanamine, 25.6 g (0.316 mole) formalin, 15 g (0.316 mole) formic acid in 350 ml DMF was heated under reflux for five hours. The mixture was partitioned between water and methylene chloride. The organic layer was dried with MgSO and evaporated in vacuo. The residue was warmed at 0.75 Torr for one hour. There was obtained 34 g (91% yield) of α,β-diethyl-3,4,5-trimethoxy-N,N dimethylbenzeneethanamine as an oil 1H NMR (CHCl3): 6.7 (s, 2H); 3.8 (s 9H); 2.7-2.2 (m, 2H); 2.2 (s, 6H); 2.0-1.2 (m, 4H); 0.9 (t, 3H); 0.7 (t, 3H).

Provenance & Evidence