反应详情

In 125 ml of acetic acid was suspended 9.77 g of 2-(2-cyclohexylethyl)-7-hydroxy-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one, and 3.5 ml of fuming nitric acid was added thereto dropwise while stirring under ice-cooling. The stirring was continued at room temperature for an additional 2.5 hours, and the precipitate formed was collected by filtration and washed successively with water, isopropanol, and diethyl ether to obtain 10.3 g of 2-(2-cyclohexylethyl)-7-hydroxy-6-nitro-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one as a pale yellow crystal.

1. additionwas added
2. temperaturecooling
3. customthe precipitate formed
4. filtrationwas collected by filtration
5. washwashed successively with water, isopropanol, and diethyl ether