反应详情

Into 500 ml of toluene was dissolved 5 g of 2,2-bis(4-pyrrolidinophenyl)propionic acid. Thereto was added 3.7 g of lead dioxide and the mixture was reacted at room temperature with stirring for one hour. The lead compound was removed by filtration and the toluene layer was washed with 100 ml of 5% aqueous solution of sodium hydroxide. Toluene was removed by distillation at a reduced pressure. The residue was recrystallized from ethanol to obtain 3.3 g (yield 76%) of 1,1-bis(4-pyrrolidinophenyl)ethylene, having a melting point of 220°~223° C.

1. customthe mixture was reacted at room temperature
2. customThe lead compound was removed by filtration
3. washthe toluene layer was washed with 100 ml of 5% aqueous solution of sodium hydroxide
4. customToluene was removed by distillation at a reduced pressure
5. customThe residue was recrystallized from ethanol