4-Hydroxy-2,2,6,6-tetramethylpiperidine → 2,2,6,6-Tetramethyl-1-(prop-2-en-1-yl)piperidin-4-ol

Participants

Reaction Conditions

Reaction Steps

2,2,6,6-tetramethyl-piperidin-4ol (0.5 g, 3.18 mmol), PdCl2 (20 mg, 0.11 mmol) and di-allyl carbonate (5 ml, 36 mmol) are charged, under inert atmosphere, into a 10 ml-flask equipped with a reflux condenser. The reaction mixture is then heated to 110° C. under stirring for about 6 hours. Gas-chromatographic analysis shows that the reaction afforded the desired 1-allyl-2,2,6,6-tetramethyl-piperidin-4ol in 85% yield (calculated on the starting piperidinol) and >98% selectivity.

Provenance & Evidence