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HRID1199152

反应详情

EQUATION

反应方程式

HRID 1199152 的结构方程式

REACTANTS

反应物

2
结构：[I-].[K+]
HCID4875

Potassium iodide

IK

结构：C[C@]12CC[C@H](OCc3ccccc3)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID53764908

未命名化合物

PRODUCTS

生成物

2
结构：C[C@]12CC[C@H](I)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID53725900

未命名化合物

结构：C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)[C@H](I)C[C@@H]12
HCID69104100

未命名化合物

PROCEDURE

实验过程

Reaction of 3β,17-dihydroxyandrosta-5,16-diene 17-acetate 1 with mercuric acetate followed by treatment with potassium iodide yields the C-16αiodide which hydrolyses with acid to yield 3β-hydroxy-16α-iodoandrost-5-en-17-one, 2d. Reaction of 2d with silver fluoride yields 3β-hydroxy-16α-fluoroandrost-5-en-17-one, 2a.

WORKUP

后处理

  1. customyields the C-16αiodide which