Triethyl phosphite → HCID 19980030, compound

HRID 1199288Notes

Reaction equation

HRID 1199288 reaction equation
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.[CH2:11]([O:13][P:14]([O:18]CC)[O:15][CH2:16][CH3:17])[CH3:12]>>[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7][P:14](=[O:18])([O:15][CH2:16][CH3:17])[O:13][CH2:11][CH3:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 701281-(Chloromethyl)-4-(methylthio)benzene2×

Product 1

HCID 19980030HCID 19980030, compound

Procedure

4-Methylmercaptobenzyl chloride (Example 4, 160 g, 0.94 mol) was added dropwise, under nitrogen, with stirring to 183 g (1.1 mol) of triethylphosphite which was heated at reflux. When the addition of the 4-methylmercaptobenzyl chloride was completed, the mixture was refluxed for additional 4 hours. The product was distilled in vacuo to yield 229 g (89%) of a colorless, viscous oil bp 142°-145° C. (0.025 mm).

Workup

  1. temperaturewas heated
  2. temperatureat reflux
  3. temperaturethe mixture was refluxed for additional 4 hours
  4. distillationThe product was distilled in vacuo

Sources & evidence

ORD record
ord-e73232ff25a94cddb67b12cd4fc2b127
Source dataset
uspto-grants-1990_02
Patent number
US04900127

Reaction notes

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