Hydrochloric Acid → N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide

Participants

Reaction Steps

To a stirring solution of the N-oxide of 3-methyl-2-pyridinesulfonamide (150 mg, 0.79 mmol) and the phenylcarbamate of 4,6-dimethyl-2-aminopyrimidine (194 mg, 0.79 mmol) in 3 mL of CH3CN was added DBU (121 mg, 0.79 mmol). The solution was stirred for 15 minutes. Three mL of H2O, then 3 mL of 5% HCl was added to the reaction and the resulting solid was collected,d m.p. 161°-163° C. NMR (200 MHz, d6 -DMS0) δ 2,36 (s, 6H), 2.59 (s, 3H), 6.97 (s, 1H), 7.4 (d, 1H), 7.5 (d, 1H), 8.3 (d, 1H), 10.6 (br s, 1H) and 13.3 (br s, 1H).

Provenance & Evidence