反应详情

Sodium borohydride (10 g) is added with stirring to a solution, boiling under reflux, of 1-methyl-4-(2,4,6-trimethoxyphenyl)-piperidin-3-one in absolute ethanol. Stirring and heating under reflux is then continued for a further hour. On cooling, the reaction mixture is diluted with water, then concentrated in order to remove the ethanol and extracted with chloroform. The chloroform extract is washed with water, dried over anhydrous sodium sulfate and concentrated to give a solid residue which, on crystallization from acetone, gives the desired product (29.2 g) of melting point 124°-125° C.

1. stirringStirring
2. temperatureheating
3. temperatureunder reflux
4. waitis then continued for a further hour
5. temperatureOn cooling
6. concentrationconcentrated in order
7. customto remove the ethanol
8. extractionextracted with chloroform
9. extractionThe chloroform extract
10. washis washed with water
11. dry with materialdried over anhydrous sodium sulfate
12. concentrationconcentrated
13. customto give a solid residue which
14. customon crystallization from acetone