Water → HCID 19866472, compound

Participants

Reaction Steps

1.2 g (0.0027 mol) of 2-[3-(N-Morpholinyl)-n-propyl]- 4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]-triazolo[4,3-a][1,4]diazepine in 20 ml of anhydrous THF are added dropwise to a prepared suspension of 0.1 g (0.0027 mol) of lithium aluminium hydride in 20 ml of anhydrous THF at ambient temperature and the mixture is refluxed for one hour. 0.1 ml of water, 0.1 ml of 15% sodium hydroxide solution and 0.3 ml of water are added to the reaction mixture which is then stirred for 30 minutes and the precipitate obtained is suction filtered. The filtrate is concentrated by evaporation, taken up in methylene chloride, washed and dried and the solvent is removed. The residue is chromatographed on silica gel using methylene chloride/methanol 95:5 as eluant. 0.16 g (yield 13%) of the desired compound are obtained, m.p. 135°-138° C.

Provenance & Evidence