Acetyl chloride → HCID 14673922, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 200 mg (0.850 m mol) of 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano [2,3-f] benzo-2,1,3-oxadiazole, 128 μl (0.917 m mol) of triethylamine and 17 ml of methylene chloride were added 128 μl (0.917 m mol) of acetyl chloride with stirring at 0° C., followed by stirring for 30 minutes. After the completion of the reaction, the precipitated crystals were filtered. The crystals were washed successively with methylene chloride and water and dried at 80° C. under reduced pressure to obtain 223 mg (yield: 88%) of the intended compound.

Provenance & Evidence