Trifluoroacetic acid → HCID 14673973, compound

Participants

Reaction Steps

To 200 mg of 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-(1-tert-butoxycarbonyl-3-oxo-pyrazolidin-2-yl)-6H-pyrano [2,3-f] benzo-2,1,3-oxadiazole were added 2 ml of trifluoroacetic acid under ice-cooling and stirred for 1 hour at the room temperature. The obtained solution was neutralized with saturated sodium bicarbonate solution and extracted with chloroform. The chloroform layer was dried over anhydrous sodium sulfate and the solvent was distilled off. The residue was added with ethyl acetate-diethyl ether (1:1) and the precipitated crystals were filtered to obtain the intended compound as colorless crystals. (Yield: 130 mg, yield: 84%)

Provenance & Evidence