Trifluoroacetic anhydride → HCID 54358424, compound

Participants

Reaction Steps

The product of step (d) above (1.61 g) and trifluoroacetic anhydride (1.79 ml) were heated under reflux in dichloromethane (50 ml) producing a copious white precipitate during 1.5 hour. The solvent was evaporated off and the residue was heated under reflux with methanol (10 ml) and triethylamine (10 ml) for 0.5 hour. Evaporation to dryness in vacuo, aqueous work-up, extraction in ethyl acetate and chromatography gave the sub-title compound as a gum. MS (FAB) 445 (M+1), (5%), 222 (100%).

Provenance & Evidence