反应详情

A solution of 2-aminopyridine (1.63 g) and 2-bromo-1-(2-bromophenyl)-ethanone (4.8 g) in dry ethanol (40 mls) was heated under reflux for 1 hour. The mixture was concentrated in vacuo. The residue was treated with dilute sodium bicarbonate solution and extracted with ethyl acetate. The ethyl acetate was washed with water and brine then dried and evaporated. Flash chromatography produced the sub-title compound as a light grey oil. MS MW 272/274 bp 272.

1. temperatureunder reflux for 1 hour
2. concentrationThe mixture was concentrated in vacuo
3. additionThe residue was treated with dilute sodium bicarbonate solution
4. extractionextracted with ethyl acetate
5. washThe ethyl acetate was washed with water and brine
6. customthen dried
7. customevaporated