Sodium Hydroxide → HCID 178509267, compound

HRID 1199485Notes

Reaction equation

HRID 1199485 reaction equation
C[N:2]([CH:4]=[C:5]([C:8](=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:6]#[N:7])C.[N+:16]([O-])(O)=O.NNC(N)=N.[OH-].[Na+]>C(O)C>[NH2:2][C:4]1[C:5]([C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:15])=[CH:6][NH:7][N:16]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 38455902-[(Dimethylamino)methylene]-3-oxo-3-phenylpropanenitrileHCID 178513186HCID 178513186, compound

Product 1

HCID 178509267HCID 178509267, compoundYield 24.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A reaction mixture comprisng 73.36 g of α-[(dimethylamino)methylene]-β-oxo-2-benzenepropanenitrile, 63.45 g of aminoguanidine nitrate, 500 ml of ethanol and 36.6 ml of 10N sodium hydroxide was refluxed for 10 hours and then cooled. The resulting precipitate was collected and washed with water, giving 17.1 g of the desired product, mp 177°-179° C.

Workup

  1. temperaturecooled
  2. customThe resulting precipitate was collected
  3. washwashed with water

Sources & evidence

ORD record
ord-ecb6dd84699b48ab807954f0301761d6
Source dataset
uspto-grants-1990_02
Patent number
US04900836

Reaction notes

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