Hydrochloric Acid → HCID 14519537, Verbindung

HRID 1199497Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1199497
[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[NH:8][N:7]=1)[CH3:2].CC(C)([O-])C.[K+].Cl[CH2:25][CH2:26][C:27]#[N:28].Cl>CN(C)C=O>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[N:8]([CH2:25][CH2:26][C:27]#[N:28])[N:7]=1)[CH3:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 109633-ChloropropionitrileHCID 348622Ethyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetateHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 14519537HCID 14519537, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of ethyl-4-oxo-3-H-phthalazin-1-ylacetate (10.91 g) and dry potassium t-butoxide (5.90 g) in dimethylformamide (50 ml) was added 3-chloropropionitrile (4.92 g) and the resulting solution was stirred for 30 minutes. The solution was then poured onto ice-water (300 ml); sufficient 10% HCl was added to adjust the pH of the resulting mixture to about 4.0 and the precipitated solid was collected and crystallized from methanol (yield: 7.64 g; m.p. 125°-126° C.).

Aufarbeitung

  1. additionThe solution was then poured onto ice-water (300 ml)
  2. customthe precipitated solid was collected
  3. customcrystallized from methanol (yield: 7.64 g; m.p. 125°-126° C.)

Quellen und Nachweise

ORD-Eintrag
ord-8d9f440bc4e042a18a35e8d50acb0d9e
Quelldatensatz
uspto-grants-1990_02
Patentnummer
US04900844

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