反应详情

A mixture of ethyl-4-oxo-3-H-phthalazin-1-ylacetate (23.42 g), ethanol (200 ml) and aqueous formaldehyde (37% concentration, 100 ml) was refluxed for 40 hours. This solution was concentrated to 100 ml and was then poured onto ice water (750 ml). The precipitated solid was collected and air-dried (yield: 17.1 g; m.p. 113°-114° C.).

1. temperaturewas refluxed for 40 hours
2. concentrationThis solution was concentrated to 100 ml
3. additionwas then poured onto ice water (750 ml)
4. customThe precipitated solid was collected
5. customair-dried (yield: 17.1 g; m.p. 113°-114° C.)