Formaldehyde → HCID 14519539, compound

HRID 1199499Notes

Reaction equation

HRID 1199499 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[NH:7][N:6]=1.[CH2:17]=[O:18]>CO>[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8](=[O:15])[N:7]([CH2:17][OH:18])[N:6]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 778234HCID 778234, compound

Product 1

HCID 14519539HCID 14519539, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of methyl-4-oxo-3-H-phthalazin-1-ylacetate (2.18 g), methanol (50 ml) and aqueous formaldehyde (37% concentration, 10 ml) was refluxed for 40 hours. The reaction mixture was cooled to room temperature and then poured onto water (50 ml). The resulting solid was collected and crystallized from methanol (yield: 0.5 g; m.p. 154°-155° C.).

Workup

  1. temperaturewas refluxed for 40 hours
  2. additionpoured onto water (50 ml)
  3. customThe resulting solid was collected
  4. customcrystallized from methanol (yield: 0.5 g; m.p. 154°-155° C.)

Sources & evidence

ORD record
ord-79e0c99d95864a9aae08810eb1106a1f
Source dataset
uspto-grants-1990_02
Patent number
US04900844

Reaction notes

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