HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate → Ethyl-3-(5,7-difluorobenzothiazol-2-ylmethyl)-4-oxo-3-H-phthalazin-1-ylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate | HCID 2821704 | — |
| Reactant | 2-Amino-4,6-difluorothiophenol hydrochloride | HCID 19789641 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl-3-(5,7-difluorobenzothiazol-2-ylmethyl)-4-oxo-3-H-phthalazin-1-ylacetate | HCID 14519544 | — |
Reaction Steps
A mixture of ethyl-3-cyanomethyl-4-oxo-phthalazin-1-ylacetate (1.29 g), 2-amino-4,6-difluoro-thiophenol hydrochloride (0.98 g) and ethanol (20 ml) was refluxed for 6 hours. Upon cooling, the title compound precipitated out as a pale yellow solid (yield: 1.62 g; m.p. 115°-117° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04900844 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-771dca1d068348e4b8026845c3ddf182 |
| Source note | uspto-grants-1990_02 |