HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Nitro-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Fluoro-2-nitrobenzotrifluoride | HCID 223094 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Nitro-3-(trifluoromethyl)aniline | HCID 94955 | — |
Reaction Steps
A solution of ammonia in water (100 cm3, s.g. 0.88) was added to 3-trifluoromethyl-4-nitrofluorobenzene (5 g) and the mixture was heated in a bomb at 150° for 2 hours. Solvent was removed in vacuo to yield a yellow solid. Recrystallization of this solid from hexane/ethyl acetate afforded yellow crystals of 4-nitro-3-trifluoromethylaniline, m.p. 134°, (3.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04900839 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-2fcae59dac3447b6aae600a778d82adc |
| Source note | uspto-grants-1990_02 |