Bromine → 4-(4-Amino-3-bromo-5-trifluoromethylphenyl)-1,2,4-triazole

HRID 1199540Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[N:11][N:10]=[CH:9]2)=[CH:4][C:3]=1[C:13]([F:16])([F:15])[F:14].[Br:17]Br.C([O-])(=O)C.[Na+]>>[NH2:1][C:2]1[C:3]([C:13]([F:16])([F:15])[F:14])=[CH:4][C:5]([N:8]2[CH:9]=[N:10][N:11]=[CH:12]2)=[CH:6][C:7]=1[Br:17]

Participants

Reactant 3

HCID 24408Bromine

HCID 517045Sodium Acetate

HCID 198670854-(4-Amino-3-trifluoromethylphenyl)-1,2,4-triazole

Product 1

HCID 198670724-(4-Amino-3-bromo-5-trifluoromethylphenyl)-1,2,4-triazole

Procedure

The following compound, m.p. 202°-3°, was prepared similarly to the previous Preparation using 4-(4-amino-3-trifluoromethylphenyl)-1,2,4-triazole, bromine, and sodium acetate (in place of hydrogen bromide and acetic acid) as the starting materials: ##STR146##

Workup

customThe following compound, m.p. 202°-3°, was prepared similarly to the previous Preparation

Sources & evidence

ORD record: ord-041347e3361849be8ac2ad8e8905d459
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04900839

Reaction notes

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